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Two isomeric conformationally restricted analogues of 4-trifluoromethylpiperidine were designed. The synthesis was performed in four steps from commercially available N -benzylmaleimide. The key reaction was the [3+2] cycloaddition between trifluoromethyldiazomethane and N -benzylmaleimide.
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Mykhailiuk et al. (2012) studied this question.
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