Key result
Fibrinolytic shutdown is characterized by an initial thrombin and plasmin burst followed by diminished fibrinolysis mediated by increased TAFI.
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Fibrinolytic shutdown involves a complex mechanism mediated by increased TAFI, suggesting that single-variable explanations are insufficient.
Fibrinolytic shutdown (versus hypofibrinolysis) = plasmin burst followed by diminished fibrinolysis. After thrombin and plasmin burst, fibrinolysis is inhibited, mediated by increased TAFI. #TAFI #TIC #surgscience @JuliaColemanMD @CUDeptSurg @DenverHealthMed @OhioStateSurg @mitchelljayc
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Coleman et al. (2023) studied this question. Fibrinolytic shutdown is characterized by an initial thrombin and plasmin burst followed by diminished fibrinolysis mediated by increased TAFI.
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