Bone Formation in Normal and Vitamin D-Treated Rachitic Rats During the Administration of Polyphosphates.

Rats were given Graham salt (a long chain polyphosphate) at dose levels which prevent calciphylactic reactions in skin and the ectopic calcification of the aorta caused by large doses of vit. D. Graham salt given at this dose level to growing rats had no effect upon the normal calcification sequences in the epiphyses, nor did it affect the cure of rickets by physiological doses of vit. D. The significance of these results is discussed.