Key result
ACE gene polymorphism shows no association with schizophrenia, major depression, bipolar disorder, or tardive dyskinesia.
Why the study?
Angiotensin converting enzyme (ACE) gene insertion/deletion polymorphism has been proposed as a candidate genetic factor for psychiatric disorders, but its association with schizophrenia, major affective disorder, and tardive dyskinesia remains unclear.
Is the ACE gene insertion/deletion polymorphism associated with schizophrenia, major depression, bipolar disorder, or tardive dyskinesia?
Case-Control
Is the ACE gene insertion/deletion polymorphism associated with schizophrenia, major depression, bipolar disorder, or tardive dyskinesia?
The ACE gene insertion/deletion polymorphism does not appear to be associated with schizophrenia, major depression, bipolar disorder, or tardive dyskinesia.
No clinical action indicated; leaves open ACE variants in psychiatric genetics for larger studies.
Angiotensin converting enzyme (ACE) is a candidate gene for psychiatric disorders. We examined the frequency of a functional insertion/deletion (I/D) polymorphism in the 16th intron of the ACE gene (located on chromosome 17q23) in groups of patients with schizophrenia (n = 104 and 113), major depression (n = 55), and bipolar disorder (n = 87) compared to healthy control subjects (n = 87). There was no evidence for allelic or genotypic association of the polymorphism with any of the disorders or with tardive dyskinesia (TD) in patients with schizophrenia. In a sample of nuclear families (n = 61) made up of one or more patients with schizophrenia recruited with their parents, there was no evidence for biased transmission of ACE I/D alleles. Particularly in the case of schizophrenia, these findings do not support an association of the ACE I/D polymorphism with the phenotypes examined.
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Segman et al. (2002) conducted a case-control in Schizophrenia, major depression, bipolar disorder, tardive dyskinesia. Angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism vs. Healthy control subjects and unbiased transmission was evaluated on Allelic or genotypic association with psychiatric disorders or tardive dyskinesia, and biased transmission in families. The ACE gene insertion/deletion polymorphism showed no allelic, genotypic, or family-based transmission association with schizophrenia, major depression, bipolar disorder, or tardive dyskinesia.
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