Key result
Preterm premature rupture of membranes (PPROM) is associated with an increased risk for adverse neurodevelopmental outcomes, particularly when complicated by intrauterine infection.
Why the study?
Preterm premature rupture of membranes (PPROM) is associated with increased risk for adverse neurodevelopmental outcomes, but the mechanisms and effects of interventions are not fully understood.
PPROM is associated with increased risk for adverse neurodevelopmental outcomes, with intrauterine infection being a particularly important risk factor.
There is increasing evidence that preterm premature rupture of membranes (PPROM) is associated with increased risk for adverse neurodevelopmental outcomes through multiple mechanisms, including preterm birth and its antecedent etiologies. Intrauterine infection is a particularly important risk factor for adverse neurodevelopmental outcomes after PPROM. This review focuses on the long-term neurodevelopmental outcomes after PPROM, the possible etiologic mechanisms of neurological injury, and the effect of antenatal and perinatal interventions using available evidence.
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Clark et al. (2011) conducted a review in Preterm premature rupture of membranes (PPROM). Preterm premature rupture of membranes (PPROM) was evaluated on Long-term neurodevelopmental outcomes. Preterm premature rupture of membranes (PPROM) is associated with an increased risk for adverse neurodevelopmental outcomes, particularly when complicated by intrauterine infection.
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