California Encephalitis Virus

Excerpt California encephalitis virus is an ungrouped neurotropic arthropod-borne virus first isolated in Kern County, Calif., in 1943. Only four cases in humans have been described in detail (1, 2). Recently there have been a number of brief reports of human cases in various parts of the world (3-5). In 1964 the first known epidemic of this virus took place in Indiana, involving 9 patients (6),* and in Ohio, involving 34 patients (7). It is the purpose of this paper to report three serologically confirmed cases of California encephalitis virus encephalitis from the Indiana epidemic and to review the literature. CASE