Editorial: Extracellular vesicle-derived non-coding RNAs (EV-ncRNAs) and their multifaceted roles in cancer biology

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ncRNAs), extracellular vesicle-derived noncoding RNAs (EV-ncRNAs), cancer, exosomeEditorial on the Research Topic Extracellular vesicle-derived non-coding rnas (EV-ncRNAs) and their multifaceted roles in cancer biology Cell-cell interactions and intracellular communication are fundamental circumstances in a wide range of biological and pathological events.As a proven fact, in biological systems, the communication between cells and their surrounding microenvironment requires the presence of messenger molecules, cytokines, and neurotransmitters, as well as intercellular exchanges through extracellular messenger vesicles with an endosomal origin.Extracellular vesicles (EVs), especially exosomes, can act as vehicles for intracellular content such as proteins, enzymes and even nucleic acids, i.e.DNA and RNA wherein they can be protected from nucleases, proteases and other degrading substances.Exosomes can be released into body fluids and spared (1, 2).Thus, they are potent carriers of intracellular cargo to nearby and distant targets as well.Structurally, EVs are endosomally originate with bilayer lipid membranes containing unique superficial proteins and CD-markers (3).According to size and origin, EVs are subdivided into microvesicles, exosomes and apoptotic bodies.Apoptotic bodies are variable in size, ranged between 50nm up to 5µm in diameter and originate from dying cells.Microvesicles have typically smaller size (100nm up to 1µm in diameter).Like exosomes, microvesicles are involved in cellular communications.The smallest kind of EVs are exosomes, those have a diameter size between 30-150nm and originated from endosome (4).A growing body of evidence implies EVs are potent nanoparticles for research in the pathogenesis of the disease or discovering new diagnostic, in addition to prognostic or therapeutic target candidate biomarkers.Studying of EVs is of important since they can be released into body fluids and are detectable by relatively simple laboratory techniques (5).As EVs have intracellular origin, valuable information can be achieved through their studying.In addition, the study Frontiers in Oncology frontiersin.