A Synthesis of (+)-Herboxidiene A

All articles of this category Key steps in a stereoselective synthesis of Herboxidiene A, a diastereoisomer of the natural herbicide Herboxidiene, include a Hoppe homoaldol reaction, a copper(I)-mediated 1,2-metallate rearrangement, and a one-pot synthesis of a diene fragment from condensation of a lithiated benzothiazolyl sulfone and an aldehyde. herbicide - 1,2-metallate rearrangement - organocuprate - homoaldol reaction - Julia olefination - directed epoxidation