An isocratic reversed-phase liquid chromatographic method for the determination of chloramphenicol 1- and 3-succinate and chloramphenicol in serum within 5 minutes following precipitation with perchloric acid is described. An ion-pair chromatographic method gives the additional option of co-determination of chloramphenicol 3-glucuronide in urine and serum. An extraction method for the determination of chloramphenicol in biological tissues is presented.
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Michael Ashton (1989) studied this question.
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