Hepatocytes isolated from the little skate, Raja erinacea , oxidize sarcosine at higher rates in hypoosmotic media and at lower rates in hyperosmotic media. A similar pattern is noted for the oxidation of sarcosine by mitochondria isolated from the liver. These observations are consistent with a role for mitochondria in ridding the cell of osmotically active organic solutes during volume regulation in hypoosmotically stressed cells while allowing their accumulation during hyperosmotic volume regulation. Such a mechanism would be quantitatively more imporant in osmoconforming species but may occur in osmoregulating species as well.
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Ballantyne et al. (1986) studied this question.
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