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PRACTICAL RELEVANCE: To safely and effectively treat cats with cancer it is important to understand the drugs being used and some species-specific concerns in relation to chemotherapy. CLINICAL CHALLENGES: While many of the same principles in treating cats with chemotherapy and targeted agents hold true as for other species, including dogs, cats display altered metabolism of drugs and species-specific toxicities that can present particular challenges for veterinarians. AUDIENCE: This article is aimed at practitioners who treat feline cancer or who help manage cats undergoing cancer therapy. EVIDENCE BASE: The article reviews the known literature regarding species differences between dogs and cats relating to the use of chemotherapy and targeted therapies. For many of the drugs mentioned there are limited studies and caution must be exercised when using drugs that have a low therapeutic index.
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Michael S. Kent (2013) studied this question.
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