Answers are grounded in this paper and cite their sources.
Feeling groovy: A family of nonmacrocyclic G-quadruplex binders with alternate oxazole and pyridine motifs was prepared. The shown heptacyclic derivative exhibits an unprecedented binding preference for certain quadruplex topologies: it recognizes exclusively the human telomeric quadruplex in Na+ buffer but not in K+ buffer. This unique quadruplex binding profile is strongly dependent on the size of the ligand and may result from groove interactions.
No takes yet. Share an insight, caveat, or question.
Hamon et al. (2011) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: