BK Virus-Associated Nephropathy (BKVN), an Under-Recognized Cause of Renal Dysfunction in Severely Immunosuppressed Hematopoietic Stem Cell Transplant (HSCT) Patients: Report of 5 Cases of Bkvn and the Potential Role of CMX001 for Treatment

BKVN is reported in 8% of renal transplant (RT) patients (pts) and leads to renal failure/graft loss if untreated. In HSCT BKV is mainly associated with hemorrhagic cystitis (HC), with few BKVN cases reported to-date. In RT, treatment (tx) is primarily immunosuppression reduction, not feasible in HSCT due to the risk of graft versus host disease (GvHD). IV cidofovir (CDV) is used as adjunctive tx, but is associated with significant nephrotoxicity. At MSKCC, we have had 5 HSCT pts with tissue-proven BKVN in past 6 yrs.