BACKGROUND: Among the therapeutic possibilities for onychomycosis, chemicalnail avulsion is a logical approach to the eradication of the pathogen. METHODS: A new formulation was used as a nail lacquer containing 40% urea in a film-forming solution in 10 patients presenting with onychomycosis. The urea nail lacquer was applied with a brush twice a day for 1 week by the patient and for a further week in two patients presenting total dystrophic onychomycosis. RESULTS: This transungual delivery system weakens the nail plate/nail bed attachment in the diseased area. CONCLUSION: The urea nail lacquer is comfortable for the patient and allows easy removal of the affected part of the fungal nail plate.
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Baran et al. (2002) studied this question.
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