Review of the Total Synthesis of the Aromatic Abietane Diterpenoid Ferruginol

The biological properties and synthesis of ferruginol as a classical abietane-type diterpenoid with an aromatic C ring are reviewed. A strategy overview from 1954 to 2023 toward the total synthesis of ferruginol may provide some references for the future design and synthesis of new diterpenoids natural products. 1 Introduction 2 Biological Activity of Ferruginol 3 Strategies toward the Total Synthesis of Ferruginol 3.1 Bogert–Cook Synthesis 3.2 Robinson Annulation 3.3 Domino Synthesis 3.4 Intramolecular Friedel–Crafts Alkylation 3.5 Oxidative Free-Radical Cyclization 3.6 Polyene Cyclization 4 Conclusion and Perspectives