Key result
Simultaneous IVUS-guided left main stenting and ASD closure succeeds in a 28-year-old woman.
Why the study?
Clinically significant coronary artery disease may occasionally coexist silently in young adults undergoing transcatheter ASD closure, but routine coronary angiography is generally not recommended without ischemic symptoms or risk factors.
Case Report (n=1)
This case highlights the potential for occult, prognostically significant coronary artery disease in young adults undergoing congenital heart interventions, supporting individualized coronary evaluation.
May support coronary evaluation in young adults undergoing ASD closure; leaves open the role of simultaneous interventions.
Transcatheter device closure is the preferred treatment for secundum atrial septal defect (ASD) in young adults with suitable anatomy. In this population, routine coronary angiography is generally not recommended in the absence of ischemic symptoms or conventional cardiovascular risk factors. However, coronary imaging is selectively performed during ASD intervention to delineate anomalous coronary anatomy at risk of device-related compression, and emerging evidence indicates that clinically significant coronary artery disease may occasionally coexist silently in younger adults. We report the case of a 28-year-old asymptomatic woman undergoing transcatheter closure of a large secundum ASD with deficient rims, in whom coronary angiography performed during invasive catheterization unexpectedly revealed critical left main coronary artery stenosis. Intravascular ultrasound (IVUS) confirmed severe luminal compromise, and successful IVUS-guided left main coronary stenting was performed, followed by device-assisted ASD closure in the same procedural session. Retrospective clinical assessment revealed a history of premature sudden cardiac death in a first-degree relative. This case illustrates the potential for occult yet prognostically significant coronary artery disease in young adults undergoing congenital heart interventions and supports a selective, individualized, and context-driven approach to coronary evaluation, consistent with contemporary adult congenital heart disease guidelines.
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Singhi et al. (2026) conducted a case report in Secundum atrial septal defect and critical left main coronary artery stenosis (n=1). Simultaneous IVUS-guided left main coronary stenting and device-assisted ASD closure was evaluated. Simultaneous IVUS-guided left main coronary stenting and device-assisted ASD closure was successfully performed in a 28-year-old woman with an unexpected critical left main coronary artery stenosis.
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