Key result
Primary antiphospholipid syndrome presenting with LV thrombus and systemic embolism carries ~22% mortality despite treatment.
Why the study?
Antiphospholipid syndrome is characterized by recurrent thrombosis and can present with left ventricular thrombus causing systemic embolism, but detailed case reports and literature reviews are limited.
Case Report (n=1)
Left ventricular thrombus in primary antiphospholipid syndrome commonly presents with systemic embolism and carries a high mortality rate, highlighting the need for thrombophilic workup in young patients with systemic thromboembolism.
Supports APS evaluation in young patients with unexplained LV thrombus; leaves open optimal therapy given high mortality in case-level data.
Antiphospholipid syndrome (APLS) is characterized by recurrent thrombosis. We report the case of a 36-year-old male who had acute right-sided ischemic stroke and right leg ischemia secondary to left ventricular (LV) thrombus caused by primary APLS. The literature review suggested that the LV thrombus presented most commonly with systemic embolism and was associated with a mortality rate of 22.2% with treatment. Thrombophilic workup in young patients with a systemic thromboembolic episode (s) is advised.
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Shashivardhan et al. (2020) conducted a case report in Primary antiphospholipid antibody syndrome (n=1). Primary antiphospholipid antibody syndrome with left ventricular thrombus was evaluated on Mortality rate (from literature review). Primary antiphospholipid syndrome can present with left ventricular thrombus and systemic embolism, which is associated with a 22.2% mortality rate despite treatment based on a literature review.
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