Key result
HRCT reveals centrilobular ground-glass nodules in ~61% of patients with metastatic pulmonary calcification.
Why the study?
The study aimed to evaluate the high-resolution computed tomography findings in patients diagnosed with metastatic pulmonary calcification to better characterize imaging patterns.
Observational (n=23)
Yes
Metastatic pulmonary calcification manifests with three main patterns on HRCT, most commonly centrilobular ground-glass nodules, which should suggest the diagnosis in the setting of hypercalcemia.
Answers are grounded in this paper and cite their sources.
HRCT patterns in 23 MPC cases described; leaves open prospective validation of diagnostic criteria.
Objective: The aim of this study was to evaluate the high-resolution computed tomography (HRCT) findings in patients diagnosed with metastatic pulmonary calcification (MPC). Materials and Methods: We retrospectively reviewed the HRCT findings from 23 cases of MPC [14 men, 9 women; mean age, 54.3 (range, 26-89) years]. The patients were examined between 2000 and 2014 in nine tertiary hospitals in Brazil, Chile, and Canada. Diagnoses were established by histopathologic study in 18 patients and clinical-radiological correlation in 5 patients. Two chest radiologists analyzed the images and reached decisions by consensus. Results: The predominant HRCT findings were centrilobular ground-glass nodules (n = 14; 60.9%), consolidation with high attenuation (n = 10; 43.5%), small dense nodules (n = 9; 39.1%), peripheral reticular opacities associated with small calcified nodules (n = 5; 21.7%), and ground-glass opacities without centrilobular ground-glass nodular opacity (n = 5; 21.7%). Vascular calcification within the chest wall was found in four cases and pleural effusion was observed in five cases. The abnormalities were bilateral in 21 cases. Conclusion: MPC manifested with three main patterns on HRCT, most commonly centrilobular ground-glass nodules, often containing calcifications, followed by dense consolidation and small solid nodules, most of which were calcified. We also described another pattern of peripheral reticular opacities associated with small calcified nodules. These findings should suggest the diagnosis of MPC in the setting of hypercalcemia.
No takes yet. Share an insight, caveat, or question.
Belém et al. (2017) conducted an observational in Metastatic pulmonary calcification (n=23). High-resolution computed tomography (HRCT) was evaluated on Predominant HRCT findings. High-resolution computed tomography in patients with metastatic pulmonary calcification most commonly demonstrated centrilobular ground-glass nodules (60.9%) and dense consolidation (43.5%).
Synapse has enriched 10 related papers. Consider them for comparative context: