Key result
Surgical myectomy and alcohol ablation for oHCM linked to increased post-procedure costs.
Why the study?
Patients with obstructive hypertrophic cardiomyopathy undergoing septal reduction therapies have high healthcare resource utilization and costs that need quantification.
What are the healthcare resource utilization and costs associated with septal reduction therapy in adults with obstructive hypertrophic cardiomyopathy?
Observational (n=119)
What are the healthcare resource utilization and costs associated with septal reduction therapy in adults with obstructive hypertrophic cardiomyopathy?
Septal reduction therapies for obstructive hypertrophic cardiomyopathy are associated with significant increases in healthcare costs, primarily driven by inpatient hospitalizations and surgical expenses.
High costs after myectomy and ablation in obstructive HCM may affect procedural decisions; leaves open need for cost-effectiveness comparisons.
BACKGROUND: Patients with obstructive hypertrophic cardiomyopathy (oHCM) and severe refractory symptoms may require invasive septal reduction therapies (SRTs), either surgical septal myectomy (SM) or transcatheter alcohol septal ablation (ASA). The main objective of this study was to quantify all-cause and oHCM-related healthcare resource utilization (HCRU) and costs for patients receiving SM or ASA. METHODS: This retrospective study utilized medical and pharmacy claims submitted during 2012-2020. HCRU and costs for 119 adults with oHCM who had at least 1 SM (n = 95) or ASA (n = 24) were compared for baseline and follow-up periods. RESULTS: The mean inpatient hospitalization stay was longer for SM (8.3 days) than ASA (6.0 days). Postprocedure HCM-related medication usage was greater following SM (98%) than ASA (88%). The mean number of HCM-related outpatient visits increased from pre- to post procedure (12.2 vs 15.9 in the SM group; 7.2 vs 9.5 in the ASA group), with most patients having at least 1 cardiology visit post procedure (86% of the SM group; 83% of the ASA group). Total mean HCM-related costs (reported in United States currency) increased with both procedures ($27,045 vs $119,772 in the SM group; $11,278 vs $54,351 in the ASA group), driven by increased inpatient hospitalization ($10,325 vs $112,923 in the SM group; $5509 vs $47,450 in the ASA group) and surgical costs ($6665 vs $92,031 in the SM group; $52 vs $44,815 in the ASA group). CONCLUSIONS: Our results indicate increasing costs for patients undergoing SRT, driven by inpatient hospitalizations and surgical costs. Commercially insured and Medicare Advantage patients with oHCM experience high healthcare costs and economic burden attributable to SRT.
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Butzner et al. (2022) conducted an observational in obstructive hypertrophic cardiomyopathy (oHCM) (n=119). Surgical septal myectomy (SM) vs. Transcatheter alcohol septal ablation (ASA) was evaluated on all-cause and oHCM-related healthcare resource utilization (HCRU) and costs. Surgical septal myectomy and alcohol septal ablation for obstructive hypertrophic cardiomyopathy were associated with increased post-procedure costs ($119,772 and $54,351, respectively).
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