Key result
High muscle strength is linked to ~24% lower stroke incidence independent of genetic risk.
Why the study?
The associations of muscle strength and genetic risk for stroke with stroke incidence were not well established.
Does higher muscle strength reduce the incidence of stroke across different strata of genetic risk?
Cohort (n=284,767)
Does higher muscle strength reduce the incidence of stroke across different strata of genetic risk?
Hazard Ratio: 0.76 (95% CI 0.71–0.82)
Higher muscle strength is independently associated with a lower risk of incident stroke, partially attenuating the increased risk conferred by high genetic susceptibility.
Muscle strength was associated with lower stroke risk across genetic strata; hypothesis-generating and should not yet change practice.
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Kim et al. (2021) conducted a cohort in Stroke (n=284,767). High muscle strength (top tertile) vs. Low muscle strength (bottom tertile) was evaluated on Incidence of overall stroke (HR 0.76, 95% CI 0.71-0.82). High muscle strength was associated with a lower incidence of stroke compared to low muscle strength (HR 0.76; 95% CI 0.71-0.82), independent of genetic risk.
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