⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

January 1, 1992Biomedical ResearchOpen Access

Characterization of Native and Recombinant Interleukin-1 Inhibitor on T Cell, Monocyte, and B Cell Response to Interleukin-1

Deh‐Ming Chang Roger B. Eaton Peter H. Schur

View Full Paper

Ask AI

Bookmark

Share

Abstract

The effects of human monocyte-generated and recombinant interleukin (IL)-1 inhibitor on selected T cell, monocyte and B cell functions were studied.Neither inhibited IL-1-mediated immunoglobulin production by human mononuclear cells nor zymosan-induced IL-1 production by human monocytes.However, the IL-1 inhibitors significantly suppressed IL-1alpha-induced IL-1 beta secretion and IL-1-beta-induced IL-1 alpha secretion.They also inhibited IL-1-primed IL-2 production.These observations suggest different effects of IL-1 inhibitor on different human cells; and that recombinant IL-1 inhibitor has similar biological properties to the native product.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Chang et al. (1992) studied this question.

synapsesocial.com/papers/6ab0cd214786a3c77bf7eea4 https://doi.org/10.2220/biomedres.13.113

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 related papers. Consider them for comparative context:

1Effects of propofol on the mRNA transcript abundance of CB1 receptors in rat brainBiomedical Research · Fri,
2Constant cGAS activation blunts STING signaling in DU145 prostate cancer cell lineBiomedical Research · Thu,
3Compressed residual green tea extract prevents capillary regression by inhibiting slow-to-fast muscle fiber transformation in the atrophied skeletal muscleBiomedical Research · Thu,
4Habitual exercise prior to intracerebral hemorrhage primes brain environment against injury in a dose-dependent manner of the exerciseBiomedical Research · Thu,
5CaMKII promotes BCR-induced apoptosis through Bcl-xL downregulation in immature B cellsBiomedical Research · Thu,

More from Biomedical Research

Atomic force microscopy identifies filamentous structures comprising mitotic chromosomesThu,
Differences in tumor-associated cytokine production and immune mechanisms between myofibroblastic cancer associated fibroblasts and myofibroblastsMon,
Dietary supplementation of myo-inositol for preventing fatty liver disease by altering hepatic epigenetic modifications in the transcribed regions of Fasn and Elovl6Mon,
Ultrastructural spectrum of oncocytic and chromophobe renal tumors: Insights from osmium maceration-based scanning electron microscopy of formalin-fixed tissuesMon,
Spatiotemporal dynamics of exercise-induced macrophages influences axonal regeneration after peripheral nerve injuryMon,