The strategies for the chemical design of biocompatible iron oxide nanoparticles for diverse biomedical applications are reviewed by D. Ling and T. Hyeon on page 1450. A review of the large-scale chemical synthetic methods is given first, and the chemical design strategies for biocompatible coatings are summarized. Finally, the toxicity of various kinds of iron oxide nanoparticles is reported.
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Ling et al. (2013) studied this question.