Key result
Synthetic heparin substitutes agglutinate platelets, proving too toxic for clinical use.
Why the study?
The platelet agglutinating effects and toxicity of new synthetic heparin substitutes were not well characterized for clinical use.
Do synthetic heparin substitutes cause platelet agglutination and toxicity in human and rabbit blood?
Do synthetic heparin substitutes cause platelet agglutination and toxicity in human and rabbit blood?
Synthetic heparin substitutes including hyaluronic acid, xylan, and alginic acid sulphuric acid esters cause platelet agglutination and are too toxic for clinical use.
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These substitutes agglutinate platelets and appear too toxic for clinical use; leaves open safer synthetic anticoagulants in future research.
Tage Astrup (1953) studied this question. Synthetic heparin substitutes (hyaluronic acid sulphuric acid ester, Thrombocid, Paritol) was evaluated on Platelet agglutinating effect. Synthetic heparin substitutes (hyaluronic acid sulphuric acid ester, Thrombocid, and Paritol) were found to agglutinate platelets, rendering them too toxic for clinical use.
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