Anti-Proliferative Effect of Synthesized Bakuchiol Analogues on Cultured Human Tumor Cell Lines

Bakuchiol ( 1) is an unique prenylated phenolic meroterpene found exclusively in the seeds of Psoralea corylifolia L. P. corylifolia is an annual plant of the Leguminosae family and distributed over Southeast Asian countries.Numerous biological actions of the whole extract of the plant or purified constituents have been reported as antioxidant, antiinflammatory and antibacterial activities. 1-3Compound 1 has been introduced firstly to be isolated from the species by G. Mehta et al. and the chemical structure of 1 was fully determined 3 including the absolute configuration of C-6 as (S)-chirality, 4 even the total synthesis was accomplished in 1973. 51 is the main constituent of the species and reported to exert antidiabetic, 6 antitumor effects, 7 BACE-1 inhibitory activity, 8 and hepatoprotective 9 activities.In the