Human microbiota and allergy

Human microbiota plays an important role in the development of the immune system and food tolerance.The microbiome is a complex ecosystem, in constant regulation, influenced by the diet and environmental stimulus.Although bacterial communities are present in various body sites [airways, gut, mouth and skin], the gastrointestinal is the largest and most studied host-microbiome interface.The microbiota is fundamental for maintaining homeostasis at the intestinal barrier and gut dysbiosis can contribute to inflammatory diseases.Allergy is one of the most common inflammatory disorders, characterized by a hypersensitivity to a harmless substance, and influenced by genetic and environmental factors, including the microbiota.Here, we aim to review evidences on microbiome´s influence on allergic disorders and microbiota-derived treatments.