An Abelson virus-transformed murine pre-B cell line class-switched from mu to gamma 3 or gamma 2b at the pre-B stage during culture. A class-switch was mediated by the deletion mechanism of the intervening CH genes on the active chromosome. This study showed for the first time that class-switching at the pre-B cell stage was not always confined to gamma 2b production.
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Sugiyama et al. (1986) studied this question.
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