Antibacterial activity of Aframomum melegueta was tested on salmonella spp, Escherichia coli, Shigella spp andklebsiella spp. Ethanol and distilled water were used as solvents for the extraction of the plant. The ethanolicextract was found to be most effective at high concentration of 50mg/ml on all the isolates. The zones ofinhibition of klebsiella spp, salmonella spp, E. coli and Shigella spp are 30mm,15mm,20mm,and 15mmrespectively with ethanolic extract. The aqueous extract was found to be less effective when compared withethanolic extract.The phytochemcial analysis carried out on Aframomum melegueta revealed the presence of alkaloids, tannins,saponin, steroids, cardiacglycoside, flavonoid, terpenoids and phenol. The presence of these phytochemcialssupport the use of this plant as antimicrobial agent. Aframomum melegueta can therefore be used asantimicrobial agent against the groups of Enterobacteriaceae tested.
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