The [3,3] Claisen rearrangement is a well-known reaction that has been very useful for the synthesis of o -allyl phenols. The thermally induced rearrangement could present safety and operational issues at large batch scale. Herein, we report a process that utilized a tube reactor to make 80 g of an early phase intermediate in a short time while mitigating the potential chemistry hazards. Thus, both project material demands and flow chemistry proof of concept were achieved.
No takes yet. Share an insight, caveat, or question.
Rincón et al. (2011) studied this question.