Key result
Periodic heart rate perturbation via pacing increases low-frequency arterial pressure and flow signals in canines.
Why the study?
Vital physiologic information about the cardiovascular system resides in the low-frequency range, but regular cardiac pulsations restrict frequency spectrum information below the natural heart rate.
A novel experimental technique using electrical pacing to frequency-modulate heart rate successfully increases the low-frequency content of cardiovascular signals for improved physiological analysis.
Should not inform clinical practice; leaves open paced heart rate modulation as an experimental tool for arterial signal analysis in animals.
Vital physiologic infonnation about the cardiovascular system resides in the low-frequency range of the frequency spectrum. The regularity of cardiac pulsations generaily restricts their frequency spectrum to a few lines corresponding to the hannonics of the regular wave-forms with little or no information at frequencies below the natural heart rate. To obtain accurate infonnation at frequencies above zero but below the natural heart rate, a simple experimental technique has been developed which introduces a periodic perturbation to the heart rate by electrical pacing. This frequency-modulated heart rate results in predictable increases in the low-frequency content of the pressure (F) and flow (Q) signals corresponding to the period and associated harmonics of the perturbation. Using this technique, curves are plotted for the modulus of the low-frequency hydraulic input impedance of a canine systemic arterial system.
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Ringo et al. (1982) studied this question. Periodic perturbation to the heart rate by electrical pacing was evaluated on Low-frequency content of the pressure and flow signals. Introducing a periodic perturbation to the heart rate by electrical pacing predictably increased the low-frequency content of pressure and flow signals in a canine systemic arterial system.
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