The ability of antiestrogens (tamoxifen and nafoxidine) to affect uterine ornithine decarboxylase (ODC) in the ovariectomized rat was determined. Tamoxifen citrate (1 mg or 10 mg/kg) and nafoxidine (0.5 mg/kg) markedly elevated ODC levels. Tamoxifen (1 mg/kg) given for 4 days totally inhibited the E2 (0.5 mug/kg)-mediated induction of ODC. Similarly nafoxidine (0.5 mug/kg) given once a day for 2 days inhibited the E2-mediated induction of ODC. The relation of the inhibition of ODC induction by antiestrogens to their mechanism of action as antiestrogens is discussed.
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Bulger et al. (1976) studied this question.
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