Key result
Elevated lipid ratios are linked to MI in elderly normolipidemic patients versus healthy controls.
Why the study?
The usefulness of lipid ratios in predicting coronary heart disease risk in normolipidaemic myocardial infarct patients was not well established.
Are lipid ratios useful in predicting the risk of myocardial infarction in elderly normolipidemic patients compared to healthy controls?
Case-Control (n=2,042)
Yes
Are lipid ratios useful in predicting the risk of myocardial infarction in elderly normolipidemic patients compared to healthy controls?
Lipid ratios such as TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C are significantly elevated in normolipidemic patients with myocardial infarction, suggesting their utility as risk predictors even when absolute lipid levels are normal.
Answers are grounded in this paper and cite their sources.
Lipid ratios may aid CHD risk assessment in normolipidaemic MI; leaves open prospective validation before clinical adoption.
To evaluate the usefulness of lipid ratios in predicting coronary heart disease risk in normolipidaemic myocardial infarct (MI) patients and compare the findings with healthy controls. Lipid profile was determined in 1 021 normolipidaemic myocardial infarct patients and was compared with 1 021 age/sex-matched controls. Total cholesterol (TC), triglycerides (TG) and HDL-cholesterol (HDL-C) were analyzed enzymatically using kits obtained from Randox Laboratories Limited, Crumlin, UK. Plasma LDL-cholesterol (LDL-C) was determined from the values of TC and HDL-C using the friedwald's formula. The values were expressed as mean±SD and data from patients and controls were compared using students' t-test. TC, TC/HDL-C ratio, TG, LDL-C, LDL-C/HDL-C ratio were higher in MI patients (P<0.001). HDL-C concentration was significantly lower in MI patients than controls (P<0.001). Higher ratio of TC/HDL-C, TG/HDL-C and LDL-C/HDL-C was observed in acute myocardial infarct patients as compared with controls. Establishment of lipid ratio from routine lipid profile assay could be very useful in predicting the future risk of acute mocardial infarction.
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Kumar et al. (2011) conducted a case-control in Myocardial infarction (n=2,042). Lipid ratios (TC/HDL-C, TG/HDL-C, LDL-C/HDL-C) vs. Healthy controls was evaluated on Lipid profile differences (TC, TG, HDL-C, LDL-C, and their ratios) (p=<0.001). Lipid ratios including TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C were significantly higher in elderly normolipidemic myocardial infarction patients compared to healthy controls (P<0.001).
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