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Summary:Poly(amidoamine)s are biocompatible biodegradable polymers, which can be easily functionalized with a number of bioactive and biomimetic compounds. Co‐polymerization of these polymers with 4‐aminobutyl guanidine (agmatine) leads to an RGD mimicking structure. Hydrogels based on this structure showed an enhanced cell adhesion and could be chemically linked to a glass substrate to create a bioadhesive support for cell growth. Preliminary optimization and cell adhesion tests on Madin‐Darby Canine Kidney cells were performed, both on functionalized and non‐functionalized structures, with promising results.
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Emilitri et al. (2008) studied this question.
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