Novel biodegradable polymers enable chemoselective ligand immobilization. α-Ketoglutaric acid and tetra(ethylene glycol) were polymerized to generate a poly(ester ether) with a ketone in the repeat unit. Treatment of this polymer with oxyamine-containing ligands allowed the selective introduction of functionality. By capping each chain with cross-linking groups, the polyester can be molded by UV irradiation. After curing, films can be functionalized to tune degradation rates and to act as a noncytotoxic, biospecific ligand-mediated cell adhesive scaffolds.
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Barrett et al. (2007) studied this question.
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