In order to determine quantitatively the participation of the spleen and the bone marrow separately, five groups of splenectomized and non-splenectomized mice totalling 87 individuals were exposed to a simulated altitude of 15,000 feet continuously for periods of 30–58 days. RBC counts and hematocrit determinations were made at various intervals. It was found that about two-fifths of the increase in red cells could be referred to a tonic contraction of the spleen and the remaining three-fifths to the production of red cells by the bone marrow.
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Cook et al. (1956) studied this question.