Key result
Cardiac autonomic neuropathy affects ~80% of T2D patients with microalbuminuria and correlates with albuminuria severity.
Why the study?
Cardiovascular autonomic dysfunction is a serious complication of type-2 diabetes and is independently associated with microalbuminuria, but its prevalence in this population was not well defined.
Observational (n=50)
No
A high prevalence (80%) of cardiac autonomic neuropathy was observed in type-2 diabetes patients with microalbuminuria, highlighting the need for routine autonomic function monitoring in this population.
Supports consideration of autonomic testing in type-2 diabetes with microalbuminuria; leaves open whether screening improves outcomes.
Background: Cardiovascular autonomic dysfunction is a serious complication of diabetes mellitus (DM) and is independently associated with microalbuminuria in patients with type-2 DM. This study was conducted to determine the prevalence of cardiovascular autonomic dysfunction in type-2 diabetes patients with microalbuminuria.Materials & Methods: This descriptive type of observational study was done in the department of Medicine, Dhaka Medical College Hospital from August 2015 to January 2016.Results: A total of 50 patients was included in the study with male predominance (M:F ratio 2. 22:1). Peak age was between 40-60 years and majority of patients (32%) was between 41-50 years and mean duration of DM was more than 12 years. Out of 50 patients, 19 (38%) patients had mild microalbuminuria; 24 (48%) patients had moderate microalbuminuria and 7 (14%) patients had severe microalbuminuria. Common symptoms were lethargy, anorexia, nausea, vomiting, dizziness and bladder symptoms. Cardiac autonomic neuropathy (CAN) was found in 80% cases. Parasympathetic dysfunction was observed in 40 (80%) cases and sympathetic dysfunction was observed in 43 (86%) cases.Conclusion: As significant number of DM patients (80%) develop CAN, so cardiovascular autonomic function tests should be monitored to address major potential cardiovascular complications even in asymptomatic patients, especially among those with microalbuminuria.J MEDICINE JUL 2018; 19 (2) : 104-109
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Miah et al. (2018) conducted an observational in Type-2 Diabetes with Microalbuminuria (n=50). Microalbuminuria in Type-2 Diabetes was evaluated on Prevalence of cardiac autonomic neuropathy (CAN). Cardiac autonomic neuropathy was highly prevalent, affecting 80% of type-2 diabetes patients with microalbuminuria, with autonomic dysfunction severity correlating with microalbuminuria grade.
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