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A series of 8‐substituted‐7‐fluoro‐5‐oxo‐5H‐thiazolo[3,2‐a]quinoline‐4‐carboxylic acids was prepared and evaluated for antibacterial activity. These compounds were synthesized from ethyl 2‐mercaptoquinoline‐3‐carboxylates 17 which were obtained from anilines 11 by a route involving an intramolecular cyclization reaction.
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Segawa et al. (1992) studied this question.
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