Key result
Asymptomatic T2D linked to ~6-fold higher 10-year cardiovascular risk versus healthy controls.
Why the study?
The cardiovascular risk of patients with Type 2 diabetes of Indo-Asian descent has never been objectively assessed despite their higher prevalence of cardiovascular disease.
What is the 10-year cardiovascular disease risk as assessed by the QRISK3 calculator in Indian patients with asymptomatic Type 2 diabetes?
Cross-Sectional (n=1,538)
Yes
What is the 10-year cardiovascular disease risk as assessed by the QRISK3 calculator in Indian patients with asymptomatic Type 2 diabetes?
Indian patients with asymptomatic Type 2 diabetes have a significantly elevated 10-year cardiovascular risk compared to healthy controls, with over 50% of men >45 years and women >55 years at high risk.
Answers are grounded in this paper and cite their sources.
Supports QRISK3 assessment in asymptomatic Indian T2D outpatients; leaves open prospective outcome trials.
BACKGROUND: The cardiovascular (CV) risk of patients with Type 2 diabetes (T2D) of Indo-Asian descent has never been objectively assessed, although it is documented that they have a higher prevalence of CV disease (CVD). AIMS: To identify groups of Indian patients with asymptomatic T2D who are at high risk of CVD as per the QRISK calculator. METHOD: After an adequate power calculation, a nation-wide study of patients with asymptomatic T2D was conducted. The QRISK3 scores of these patients were used to derive a 10-year risk of CV events. High CVD risk was defined as ≥20% risk of CV event in 10 years. RESULTS: For a total of 1538 patients across 154 outpatient departments, the QRISK3 scores were collated. Median 10-year CVD risk was 22.2%. Mean 10-year CVD risk was 28.4% (standard deviation 22.1%), representing a 5.7-fold increase vs. controls (i.e., matched healthy adults). Absolute CVD risk increased linearly with age. Over 50% of T2D males aged above 45 years had a high (>20%) CVD risk. Women aged more than 55 years had a high risk of CVD. More than 50% of patients with a T2D duration of more than 5 years had a high risk of CVD as per the QRISK3 calculator.
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Ghosal et al. (2020) conducted a cross-sectional in Type 2 diabetes (n=1,538). Asymptomatic Type 2 diabetes vs. Matched healthy adults was evaluated on 10-year risk of cardiovascular events (QRISK3 score) (5.7-fold increase). Asymptomatic Type 2 diabetes in Indian outpatients was associated with a mean predicted 10-year cardiovascular risk of 28.4%, a 5.7-fold increase compared to matched healthy controls.
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