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Mycosis fungoides (MF), and the leukemic variant Sézary syndrome (SS) are the most common types of cutaneous T-cell lymphomas (CTCL) characterized by a chronic course with limited therapeutic options for advanced stages of disease.1 Mogamulizumab (moga) is a monoclonal antibody therapy with enhanced antibody-dependent cellular cytotoxicity activity against the C-C motif chemokine receptor 4 receptor that is expressed on malignant T cells, facilitating their migration to the skin.2 Moga was Food and Drug Administration approved in 2018 for relapsed/refractory MF and SS.
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McIntyre et al. (2025) studied this question.
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