The effect of the natural ketones emitted by bacteria (2-nonanone, 2-heptanone, 2-undecanone) on the functioning of the Quorum Sensing (QS) systems was studied. In this work, three lux-reporter strains containing the components of the LasI/LasR, RhlI/RhlR, LuxI LuxR QS systems were used as biosensors for the N-acyl-homoserine lactones. It was shown that at concentrations of ketones that exhibited little or no bactericidal action the ketones could modulate the QS-response by suppressing the expression of the lux-operon reporter to a greater extent than the cell viability of these strains.
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Plyuta et al. (2014) studied this question.
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