Reactance of vascular endothelium at elderly patients with primary open-angle glaucoma and physiologically growing old people depending on expressiveness of endothelium dysfunction

The aim of this investigation is to study endothelial dysfunction expressiveness in patients with primary open-angle glaucoma (POUG) and physiologically ageing people. Materials and methods. The main group consisted of 64 men (122 eyes) with POUG at the age of 65.3±1.4 years. The group of control consisted of 56 men (102 eyes) of the same age without glaucoma. The biological age (BA) and a ratio of functional vasotonic bioeffectors in endothelial dysfunction were studied. Level of a stable metabolite of nitrogen oxide - nitrite (NO 2- ) and endothelin-1 (ET-1) in a blood plasma were defined. Reactive hyperemia test showed pronounced changes in vascular endothelial function in patients with glaucoma.The method is based on ability of an endothelium to secrete NO in the conditions of a reactive hyperemia. Endothelia dependent vasodilatation after decompression of a humeral artery was counted. Results. Patients with glaucoma grow older early in comparison with clinically healthy volunteers of the same age without glaucoma. It is connected with development of an endothelial dysfunction and vasomotorial answer vascular endothelia. Patients of the main group with the expressed endothelial dysfunction have constrictor reaction of a vessel after elimination of occlusion. It leads to increasing of ischemia and accelerate the progression of glaucoma. Conclusions. The endothelial reaction depends on endothelial dysfunction expressiveness and rates of physiological ageing.