Key result
2-chloroprocaine shows a ~27% shorter in vitro half-life in maternal versus fetal plasma.
Why the study?
There was a discrepancy between the reported in vitro half-life of chloroprocaine and the slower observed disappearance of the drug in maternal plasma in vivo.
What is the in vitro and in vivo half-life of 2-chloroprocaine in obstetric patients?
Observational (n=9)
What is the in vitro and in vivo half-life of 2-chloroprocaine in obstetric patients?
The apparent in vivo half-life of 2-chloroprocaine after epidural anesthesia is significantly longer (minutes) than its in vitro half-life (seconds), likely due to continuous uptake from the epidural space.
Answers are grounded in this paper and cite their sources.
Rapid in vivo clearance may favor obstetric use; leaves open clinical relevance of maternal-fetal half-life differences seen in vitro.
The purpose of this study was to examine the discrepancy between the reported in vitro half-life of chloroprocaine and the slower observed disappearance of the drug in maternal plasma. The study had two aims. The first was to redetermine the in vitro half-life of 2-chloroprocaine in maternal and fetal plasma. The second was to determine the apparent half-life of 2-chloroprocaine in vivo after intrapartum epidural anesthesia in obstetric patients. Gas chromatography or gas chromatography/mass spectrometry techniques were used to measure 2-chloroprocaine in maternal or fetal plasma. Mean in vitro half-lives of 11.2 +/- 2.8 and 15.4 +/- 5.2 sec were found for maternal and fetal plasma from nine patients, respectively. The maternal half-life was significantly shorter than the fetal half-life (P less than 0.05). The mean apparent in vivo half-life in maternal plasma was found to be 3.1 +/- 1.6 min. The results of this study show that the half-life in vitro is correctly measured in seconds. However, the apparent half-life in vivo after epidural anesthesia is 3.1 +/- 1.6 min and ranges from 1.5 to 6.4 min. The differences in the magnitude of the two findings is probably due to continuous uptake of the drug from the epidural space.
No takes yet. Share an insight, caveat, or question.
Kuhnert et al. (1986) conducted an observational in Obstetric patients requiring intrapartum epidural anesthesia (n=9). 2-chloroprocaine vs. Fetal plasma (for in vitro comparison) was evaluated on In vitro half-life of 2-chloroprocaine in maternal and fetal plasma (seconds) (p=<0.05). The in vitro half-life of 2-chloroprocaine was significantly shorter in maternal plasma (11.2 sec) than in fetal plasma (15.4 sec; P<0.05), whereas its apparent in vivo half-life was 3.1 minutes.
Synapse has enriched 10 related papers. Consider them for comparative context: