Synthesis of hyperbranched polycarbosilane modified with cyclodextrin derivatives and its application in coated capillary electrophoresis columns

A series of hyperbranched polycarbosilanes were synthesized and coated on the inner surface of fused‐silica capillaries by chemical bonding. The end groups of the hyperbranched polycarbosilanes were modified with β‐cyclodextrin derivatives. The chiral isomers of ofloxacin and chlorpheniramine were separated by this new type of chiral capillary electrophoresis column and high‐column efficiency was achieved. The results showed that ofloxacin was completely separated at pH 3.0; the separation resolution was 2.32, and theoretical plates were greater than 4.5 × 104 plates m−1.