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July 23, 2020HaematologicaOpen Access

Complement C5 inhibition in patients with COVID-19 - a promising target?

Régis Peffault de Latour Anne Bergeron Étienne Lengliné Thibault Dupont A. Marchal Lionel Galicier Nathalie De Castro Louise Bondeelle Michaël Darmon Clairelyne Dupin Guillaume Dumas Pierre Leguen Isabelle Madelaine Sylvie Chevret Jean‐Michel Molina Élie Azoulay Véronique Frémeaux‐Bacchi CORE GROUP

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Complement C5 inhibition in patients with

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Latour et al. (2020) studied this question.

synapsesocial.com/papers/6ab1d679b66599892cb3743c https://doi.org/10.3324/haematol.2020.260117

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus PathogenesisOriginal Research · 2018 · 655 citations
2Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2-mediated complement over-activationOriginal Research · 2020 · 436 citations
3Assessing complement blockade in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumabOriginal Research · 2014 · 166 citations
4COVID-19 and its implications for thrombosis and anticoagulationOriginal Research · 2020 · 2,372 citations
5Neutrophil extracellular traps in COVID-19Case-Control Study · 2020 · 1,587 citations

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