Key result
No anticoagulation after mechanical valve replacement in FX deficiency linked to 12 complication-free years.
Why the study?
Mechanical valve replacement requires long-term anticoagulation to prevent thromboembolism, but cases without anticoagulation have been rarely reported.
Case Report (n=1)
This case report highlights a rare instance where a patient with a mechanical valve and Factor X deficiency remained free of thrombosis without anticoagulation for 12 years.
FX deficiency may permit anticoagulation-free mechanical valve replacement; hypothesis-generating and should not change practice.
BACKGROUND: For patients who undergo mechanical valve replacement, the greatest disadvantage is that they require long-term or permanent use of anticoagulant therapy to prevent thromboembolism. To date, mechanical valve replacement without anticoagulation has been published in the literature. CASE SUMMARY: June, 2007. However, this patient had not been taking anticoagulant medication since she experienced warfarin overdose in the first month after the operation. She had been well without using any anticoagulation, and there were no complications of the mechanical valve. DISCUSSION: There was no thrombosis for such a long period of time because she suffered from FX deficiency. To the best of our knowledge, she may be the only patient who has been well without any anticoagulation since not taking warfarin 12 years ago.
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Wang et al. (2021) conducted a case report in Mechanical valve replacement and FX deficiency (n=1). Mechanical valve replacement without anticoagulation was evaluated on Thrombosis or complications of the mechanical valve. A patient with FX deficiency who underwent mechanical valve replacement remained free of thrombosis and valve complications for 12 years without taking any anticoagulant medication.
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