Key result
ASA plus dipyridamole is linked to greater early inhibition of Platelet Factor 4 release than monotherapy.
Why the study?
The effect on platelet function of acetylsalicylic acid, dipyridamole, and their combination in patients with transient ischaemic attacks was not fully characterized.
Does the combination of acetylsalicylic acid and dipyridamole improve inhibition of platelet function compared to either agent alone in patients with transient attacks of ischaemia?
Does the combination of acetylsalicylic acid and dipyridamole improve inhibition of platelet function compared to either agent alone in patients with transient attacks of ischaemia?
The combination of acetylsalicylic acid and dipyridamole provides earlier inhibition of Platelet Factor 4 release than either drug alone in patients with transient ischaemic attacks.
Small study shows assay-dependent platelet effects post-TIA; leaves open whether drug choice alters clinical outcomes.
Twenty patients suffering from transient attacks of ischaemia were studied. Seven received acetylsalicylic acid, six dipyridamole and seven a combination of the two drugs. No significant difference in platelet aggregation was shown in the acute phase between the three treatment groups using an adenosine diphosphate test method. Using Thrombofax platelet substitute, however, a significant difference was seen in all measures. On the seventh day following the ischaemic attack the Thrombofax values returned to normal but, in contrast, Platelet Factor 4 release was increased. Monthly testing of platelet activity during treatment shows that the combination of acetylsalicylic acid with dipyridamole was more effective in bringing about an early inhibition of Platelet Factor 4 release than either agent alone.
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Fassio et al. (1979) studied Transient attacks of ischaemia (n=20). Acetylsalicylic acid and dipyridamole combination vs. Acetylsalicylic acid alone or dipyridamole alone was evaluated on Platelet aggregation and Platelet Factor 4 release. The combination of acetylsalicylic acid and dipyridamole was more effective in bringing about an early inhibition of Platelet Factor 4 release than either agent alone.
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