). Competitive inhibition experiments showed that after the incubation with DOX-loaded glycomicelles for 4 h, more efficient killing activity against free HepG2 cells (-LBA) was observed, as compared to that against LBA-blocked HepG2 cells (+LBA) after a subsequent 72 h incubation. Glycomicelles with tailored LBA functionalities, high drug loading capacity, and high uptake by ASGP-R positive cells are promising candidates for liver cancer chemotherapy.
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Chen et al. (2015) studied this question.
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