A chemical biology view of bioactive small molecules and a binder-based approach to connect biology to precision medicines

Introduction.A simplistic view of drug discovery is that it begins, most often using "model organisms", with biological inferences of a disease that suggest the need to interfere with some activity, function or process.An enzyme should be inhibited or a pathogen should be killed.Chemical experimentation yields the desired inhibitor, and clinical investigations then test the underlying hypothesis in humans.If the stars align, an effective drug emerges.