Key result
Glutamine treatment increases aortic HSP 70 expression versus controls in diabetic rodents.
Why the study?
Diabetes mellitus alters arterial wall compliance causing aortic stiffness, and the role of glutamine-induced HSP 70 expression in this process is unclear.
Does glutamine administration alter HSP 70 expression and aortic stiffness in a rodent model of diabetes mellitus?
Population
30 male Sprague-Dawley rats with streptozocin-induced diabetes mellitus
Comparison
Glutamine-treated diabetic rats vs untreated diabetic and control rats
Design
Experimental rodent model pilot study
Authors
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Caution against clinical use of glutamine in diabetes; leaves open whether HSP70 induction improves vascular outcomes in humans.
Does glutamine administration alter HSP 70 expression and aortic stiffness in a rodent model of diabetes mellitus?
In a diabetic rodent model, glutamine administration alters HSP 70 expression, suggesting it may be a potential therapeutic target for diabetes-associated aortic stiffness.
Uğurlucan et al. (2009) studied Diabetes mellitus (n=30). Glutamine vs. Control and untreated diabetes mellitus was evaluated on Serum and aortic HSP 70 levels. In an experimental rodent model of diabetes mellitus, glutamine treatment significantly increased aortic heat shock protein 70 expression compared to controls.
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