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November 1, 1990Applied and Environmental MicrobiologyOpen Access

Stereospecific Reduction of Ethyl 2′ -Ketopantothenate to Ethyl D-(+)-Pantothenate with Microbial Cells as a Catalyst

Michihiko Kataoka Sakayu Shimizu Yukiko Doi Hideaki Yamada

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Abstract

A novel enzymatic process for the synthesis of D-(+)-pantothenic acid through the asymmetric reduction of the 2' -ketopantothenate ester is described. Candida macedoniensis AKU 4588 was found to convert ethyl 2' -ketopantothenate (80 mg/ml) almost specifically to ethyl D-(+)-pantothenate (>98% enantiomeric excess), with a molar yield of 97.2%.

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Kataoka et al. (1990) studied this question.

synapsesocial.com/papers/6ab1dc0ee2a7645356c46376 https://doi.org/10.1128/aem.56.11.3595-3597.1990

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