Key result
High WSS temporal variation and residence times strongly correlate with maximum IMT at 60 months.
Why the study?
The influence of Wall Shear Stress topological skeleton on vascular pathophysiology and its association with long-term restenosis after carotid endarterectomy is underexplored.
Does Wall Shear Stress (WSS) topological skeleton predict long-term restenosis (measured by IMT) after carotid bifurcation endarterectomy?
Cohort (n=12)
No
Does Wall Shear Stress (WSS) topological skeleton predict long-term restenosis (measured by IMT) after carotid bifurcation endarterectomy?
Effect estimate: R2 = 0.53
p-value: p=<0.05
Wall Shear Stress topological skeleton features independently predict long-term restenosis after carotid endarterectomy, providing a mechanistic link between flow disturbances and vascular lesions.
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WSS topological features may associate with post-carotid restenosis; leaves open incremental prognostic value beyond conventional risk markers.
Morbiducci et al. (2020) conducted a cohort in Carotid stenosis undergoing carotid endarterectomy (n=12). High temporal variation of WSS contraction/expansion and high fixed point residence times vs. Low exposure was evaluated on Intima-media thickness (IMT) at 60 months follow-up (R2 = 0.53, p=<0.05). Exposure to high temporal variation of wall shear stress contraction/expansion and high fixed point residence times significantly correlated with maximum intima-media thickness at 60 months (R2=0.53, p<0.05).
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